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Pennsylvania (/ ˌ p ɛ n s ɪ l ˈ v eɪ n i ə / ⓘ PEN-sil-VAY-nee-ə, lit. ' Penn's forest country '), officially the Commonwealth of Pennsylvania [b] (Pennsylvania Dutch: Pennsylvanie), [7] is a state spanning the Mid-Atlantic, Northeastern, Appalachian, and Great Lakes regions of the United States.
The intravenous dose causing 50% of opioid-naive experimental subjects to die (LD 50) is "3 mg/kg in rats, 1 mg/kg in cats, 14 mg/kg in dogs, and 0.03 mg/kg in monkeys." [ 96 ] The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. [ 97 ]
Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4][8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9]
The Federal Reserve cut its target range to 4.75%-5% on Wednesday, or a reduction of 0.5 percentage points from its prior level, which was at the highest in 23 years. The effective rate stands at ...
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