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The intravenous dose causing 50% of opioid-naive experimental subjects to die (LD 50) is "3 mg/kg in rats, 1 mg/kg in cats, 14 mg/kg in dogs, and 0.03 mg/kg in monkeys." [ 96 ] The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. [ 97 ]
The 50% top rate of income tax was reduced to 45% by the Conservative–Liberal Democrat coalition. [177] Alongside a reduction in tax and commitments to keep taxation low, the Conservative Party has significantly reduced government spending, through the austerity programme which commenced in 2010, subsequent to the 2007–2008 financial crisis .
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